Latent autoimmune diabetes in adults (LADA) should be less latent

被引：0
作者：
S. Fourlanos
F. Dotta
C. J. Greenbaum
J. P. Palmer
O. Rolandsson
P. G. Colman
L. C. Harrison
机构：
[1] The Walter and Eliza Hall Institute of Medical Research,Autoimmunity and Transplantation Division
[2] University of Siena; Policlinico Le Scotte,Diabetes Unit, Department of Internal Medicine and Department of Endocrine and Metabolic Sciences
[3] Benaroya Research Institute at Virginia Mason,Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Veterans Affairs Puget Sound Health Care System
[4] University of Washington,Family Medicine, Public Health and Clinical Medicine
[5] Umeå University,Department of Diabetes and Endocrinology
[6] The Royal Melbourne Hospital,undefined
来源：
Diabetologia | 2005年 / 48卷
关键词：
Autoimmune diabetes; Classification; Diagnostic criteria; HLA; Latent autoimmune diabetes in adults; LADA; Type 1 diabetes;
D O I：
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学科分类号：
摘要：
‘Latent autoimmune diabetes in adults’ (LADA) is the term coined to describe adults who have a slowly progressive form of autoimmune or type 1 diabetes that can be treated initially without insulin injections. The diagnosis of LADA is currently based on three clinical criteria: (1) adult age at onset of diabetes; (2) the presence of circulating islet autoantibodies, which distinguishes LADA from type 2 diabetes; and (3) insulin independence at diagnosis, which distinguishes LADA from classic type 1 diabetes. The prevalence of LADA in adults presenting with non-insulin-requiring diabetes is approximately 10%. Recognition of LADA expands the concept and prevalence of autoimmune diabetes, but LADA remains poorly understood at both a clinical and research level. In this perspective, we review the nomenclature, diagnostic criteria, genetics, pathology and therapy of LADA, to arrive at recommendations that might advance knowledge and management of this form of diabetes.
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页码：2206 / 2212
页数：6
相关论文
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