Increasing the solubility of phenazepam by forming solid dispersions

被引：0

作者：

I. I. Krasnyuk

O. V. Manakhova

R. U. Khabriev

V. A. Popkov

V. Yu. Reshetnyak

O. I. Krasnyuk

机构：

[1] Sechenov Moscow Medical Academy,

来源：

Pharmaceutical Chemistry Journal | 2010年 / 44卷

关键词：

solid dispersion; solubility; phenazepam; poly(ethyleneglycol)-1500; poly(vinylpyrrolidone)-10000; β-cyclodextrin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and β-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.

引用

页码：274 / 277

页数：3