Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways

被引:0
|
作者
Thu-Ha Tran
Ming Kao
Hsiao-Sheng Liu
Yi-Ren Hong
Yeu Su
Chi-Ying F. Huang
机构
[1] National Yang Ming Chiao Tung University and Academia Sinica,Taiwan International Graduate Program in Molecular Medicine
[2] National Yang Ming Chiao Tung University,Institute of Biopharmaceutical Sciences
[3] National Cheng Kung University,Department of Microbiology and Immunology, College of Medicine
[4] Kaohsiung Medical University,Center for Cancer Research, College of Medicine
[5] M. Sc. Program in Tropical Medicine,Graduate Institutes of Medicine, College of Medicine
[6] College of Medicine,Department of Biological Sciences
[7] Kaohsiung Medical University,Department of Medical Research
[8] Kaohsiung Medical University,Department of Biochemistry, College of Medicine
[9] National Sun Yat-Sen University,Institute of Clinical Medicine, College of Medicine
[10] Kaohsiung Medical University Hospital,Department of Biotechnology and Laboratory Science in Medicine
[11] Neuroscience Research Center,undefined
[12] Kaohsiung Medical University,undefined
[13] Kaohsiung Medical University,undefined
[14] National Yang Ming Chiao Tung University,undefined
[15] National Yang Ming Chiao Tung University,undefined
来源
Cell Communication and Signaling | / 21卷
关键词
Colorectal cancer; Thioridazine; Immunogenic cell death; Endoplasmic reticulum stress; Secretory autophagy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 48 条
  • [21] Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells
    Chakraborty, Supriya
    Ghosh, Swatilekha
    Banerjee, Bhaswati
    Santra, Abhishek
    Bhat, Jyotsna
    Adhikary, Arghya
    Chatterjee, Subhrangsu
    Misra, Anup K.
    Sen, Parimal C.
    APOPTOSIS, 2016, 21 (10) : 1106 - 1124
  • [22] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress
    Mitsuda, Teruhiko
    Omi, Tsubasa
    Tanimukai, Hitoshi
    Sakagami, Yukako
    Tagami, Shinji
    Okochi, Masayasu
    Kudo, Takashi
    Takeda, Masatoshi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 415 (03) : 519 - 525
  • [23] EIF2α/ATF4 pathway enhances proliferation of mesangial cell via cyclin D1 during endoplasmic reticulum stress in IgA nephropathy
    Lan, Zhixin
    Zhao, Lu
    Peng, Liang
    Wan, Lili
    Liu, Di
    Tang, Chengyuan
    Chen, Guochun
    Liu, Yu
    Liu, Hong
    CLINICAL IMMUNOLOGY, 2023, 257
  • [24] Periostin has a protective role in melatonin-induced cell apoptosis by inhibiting the eIF2α-ATF4 pathway in human osteoblasts
    Meng, Xiaotong
    Zhu, Yue
    Tao, Lin
    Zhao, Sichao
    Qiu, Shui
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 41 (02) : 1003 - 1012
  • [25] Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
    Kobylewski, Sarah E.
    Henderson, Kimberly A.
    Yamada, Kristin E.
    Eckhert, Curtis D.
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2017, 176 (02) : 278 - 293
  • [26] Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway
    Li, Yueyong
    Zhang, Yingjun
    Fu, Huangde
    Huang, Huadong
    Lu, Qifeng
    Qin, Houji
    Wu, Yingning
    Huang, Huatuo
    Mao, Guizhen
    Wei, Zhongheng
    Liao, Pinhu
    NEUROSCIENCE BULLETIN, 2020, 36 (02) : 134 - 142
  • [27] Endoplasmic reticulum stress participates in apoptosis of HeLa cells exposed to TPHP and OH-TPHP via the eIF2α-ATF4/ATF3-CHOP-DR5/P53 signaling pathway
    An, Jing
    Du, Chenyang
    Xue, Wanlei
    Huang, Jin
    Zhong, Yufang
    Ren, Guofa
    Shang, Yu
    Xu, Bingye
    TOXICOLOGY RESEARCH, 2023, 12 (06) : 1159 - 1170
  • [28] Ionizing radiation activates PERK/eIF2α/ATF4 signaling via ER stress-independent pathway in human vascular endothelial cells
    Kim, Eun Ju
    Lee, Yoon-Jin
    Kang, Seongman
    Lim, Young-Bin
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2014, 90 (04) : 306 - 312
  • [29] Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway
    Sun, Jing
    Chen, Wugui
    Li, Songtao
    Yang, Sizhen
    Zhang, Ying
    Hu, Xu
    Qiu, Hao
    Wu, Jigong
    Xu, Shangcheng
    Chu, Tongwei
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [30] ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2α/ATF4/CHOP axis
    Zheng, Yihu
    Zhou, Qingqing
    Zhao, Chang
    Li, Junjian
    Yu, Zhengping
    Zhu, Qiandong
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (03) : 1468 - 1479