Solid state of aceclofenac: Characterization, transformation

被引：1

作者：

Jung Soon Song

Young Taek Sohn

机构：

[1] College of Pharmacy, Duksung Women's University, Dobong-Gu, Seoul, 132-714, 419, Ssangmun-Dong

来源：

Journal of Pharmaceutical Investigation | 2012年 / 42卷 / 3期

关键词：

Aceclofenac; Crystal form; DSC; Polymorphism; PXRD; Transformation;

D O I：

10.1007/s40005-012-0022-7

中图分类号：

学科分类号：

摘要：

The objective of this work was to investigate the existence of polymorphs and pseudopolymorphs of aceclofenac which is a peripherally acting, non-steroidal anti-inflammatory analgesic with anti-inflammatory, antiarthritic and antipyretic activities. Three crystal forms of aceclofenac have been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) and thermogravimetric analysis. The DSC and PXRD patterns of the three crystal forms of aceclofenac were different respectively. After storage of 1 month at 0 % RH (silica gel, 20 °C), 52 % RH (saturated solution of Na2Cr2O7·2H2O/20 °C) and 95 % RH (saturated solution of Na2HPO4/20 °C), Form 1 and Form 3 (from methylethyl ketone) were not transformed, but Form 2 (from DMSO) was transformed to Form 1 at 95 % RH. © 2012 The Korean Society of Pharmaceutical Sciences and Technology.

引用

页码：127 / 131

页数：4

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