The effects of bee venom on liver and skeletal muscle in exhaustive swimming rats

被引:0
作者
Askin Senturk
Bahar Dalkiran
Burcu Acikgoz
Ilkay Aksu
Osman Acikgoz
Muge Kiray
机构
[1] Dokuz Eylul University,Department of Physiology, Medical Faculty
[2] Dokuz Eylul University,Graduate School of Health Sciences
来源
Biologia Futura | 2022年 / 73卷
关键词
Exhaustive exercise; Oxidative stress; Inflammation; Liver; Skeletal muscle;
D O I
暂无
中图分类号
学科分类号
摘要
Oxidative damage and proinflammatory cytokines are involved in exhaustive exercise-induced fatigue. This study aimed to investigate the effects of bee venom, a natural toxin, on fatigue and tissue damage in rats that underwent forced swimming exercise. Rats were divided into four groups: control, swimming exercise (SE), bee venom (BV) and swimming exercise + bee venom (SE + BV). SE and SE + BV groups were subjected to forced swimming (load of 7% body weight) for 5 days. BV and SE + BV groups were injected with 1 mg/kg BV subcutaneously. Swimming time, blood lactate and TNF-α levels, MDA and GSH levels in liver and gastrocnemius muscle were evaluated. Swimming time was shorter in SE + BV group than SE group. There was no difference in lactate levels between SE and SE + BV groups. MDA and GSH levels were increased in SE, BV and SE + BV groups. TNF-α levels were increased in BV group compared to control and SE groups. Our study demonstrated that BV administration before exhaustive exercise in rats did not provide anti-fatigue effect. Additionally, BV did not show anti-inflammatory activity and had different effects on antioxidant capacity at tissue level. Further research might explore the effects of different doses and durations of BV on exhaustive exercise.
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页码:237 / 244
页数:7
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