共 50 条
The effects of bee venom on liver and skeletal muscle in exhaustive swimming rats
被引:0
作者:
Askin Senturk
Bahar Dalkiran
Burcu Acikgoz
Ilkay Aksu
Osman Acikgoz
Muge Kiray
机构:
[1] Dokuz Eylul University,Department of Physiology, Medical Faculty
[2] Dokuz Eylul University,Graduate School of Health Sciences
来源:
Biologia Futura
|
2022年
/
73卷
关键词:
Exhaustive exercise;
Oxidative stress;
Inflammation;
Liver;
Skeletal muscle;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Oxidative damage and proinflammatory cytokines are involved in exhaustive exercise-induced fatigue. This study aimed to investigate the effects of bee venom, a natural toxin, on fatigue and tissue damage in rats that underwent forced swimming exercise. Rats were divided into four groups: control, swimming exercise (SE), bee venom (BV) and swimming exercise + bee venom (SE + BV). SE and SE + BV groups were subjected to forced swimming (load of 7% body weight) for 5 days. BV and SE + BV groups were injected with 1 mg/kg BV subcutaneously. Swimming time, blood lactate and TNF-α levels, MDA and GSH levels in liver and gastrocnemius muscle were evaluated. Swimming time was shorter in SE + BV group than SE group. There was no difference in lactate levels between SE and SE + BV groups. MDA and GSH levels were increased in SE, BV and SE + BV groups. TNF-α levels were increased in BV group compared to control and SE groups. Our study demonstrated that BV administration before exhaustive exercise in rats did not provide anti-fatigue effect. Additionally, BV did not show anti-inflammatory activity and had different effects on antioxidant capacity at tissue level. Further research might explore the effects of different doses and durations of BV on exhaustive exercise.
引用
收藏
页码:237 / 244
页数:7
相关论文
共 50 条