Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity

被引：0
作者：
Jigisha A. Modi
K. C. Patel
机构：
[1] V. N. S. G. University,Department of Chemistry
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Purine; Thioureido linkage; Minimum inhibitory concentration (MIC);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a–j prove to be effective with minimum inhibitory concentration (MIC) (mg ml−1), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, and elemental analysis.
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页码：1660 / 1664
页数：4
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