A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

被引：0
作者：
Luis E. Raez
Kyriakos Papadopoulos
Alejandro D. Ricart
E. Gabriella Chiorean
Robert S. DiPaola
Mark N. Stein
Caio M. Rocha Lima
James J. Schlesselman
Khaled Tolba
Virginia K. Langmuir
Stewart Kroll
Donald T. Jung
Metin Kurtoglu
Joseph Rosenblatt
Theodore J. Lampidis
机构：
[1] University of Miami,Department of Cell Biology (R
[2] Miller School of Medicine,124), Sylvester Comprehensive Cancer Center
[3] Institute for Drug Development,Department of Medicine, Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center
[4] Indiana University Melvin and Bren Simon Cancer Center,undefined
[5] UMDNJ-Cancer Institute of New Jersey,undefined
[6] Threshold Pharmaceuticals,undefined
[7] University of Miami Miller School of Medicine,undefined
来源：
Cancer Chemotherapy and Pharmacology | 2013年 / 71卷
关键词：
2-Deoxy-; -Glucose; Docetaxel; Phase I; Lung cancer; Breast cancer; Head and neck cancers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：523 / 530
页数：7
相关论文
共 153 条
[1]  
Hu Y(2000)Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs Biochem Pharmacol 60 1897-1905
[2]  
Moraes C(2001)Hypersensitization of tumor cells to glycolytic inhibitors Biochemistry 40 5542-5547
[3]  
Savaraj N(2004)Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy- Cancer Chemother Pharmacol 53 116-122
[4]  
Priebe W(2008)-glucose in tumor cells treated under hypoxic vs aerobic conditions Invest Ophthalmol Vis Sci 49 2799-2805
[5]  
Lampidis TJ(2004)Targeting hypoxia, a novel treatment for advanced retinoblastoma Cancer Res 64 31-34
[6]  
Liu H(1956)2-deoxy- Science 123 309-314
[7]  
Hu Y(2006)-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo Cancer Res 66 8927-8930
[8]  
Savaraj N(1998)On the origin of the cancer cells Proc Natl Acad Sci USA 95 1511-1516
[9]  
Priebe W(2005)Cancer’s molecular sweet tooth and the Warburg effect Proc Natl Acad Sci USA 102 5992-5997
[10]  
Lampidis T(2006)A unique glucose-dependent apoptotic pathway induced by c-Myc Science 16 1650-1653
12345678910