Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34+ cells

被引：0
作者：
Zheng Hu
Yong-Guang Yang
机构：
[1] Columbia Center for Translational Immunology,
[2] Columbia University College of Physicians and Surgeons,undefined
[3] First Bethune Hospital of Jilin University,undefined
来源：
Cellular & Molecular Immunology | 2012年 / 9卷
关键词：
humanized mouse; hematopoiesis; immune system; immunodeficient mouse; thymopoiesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous efforts have been devoted towards the development of such humanized mouse models. This review is focused on human lymphohematopoietic reconstitution and immune function in humanized mice by cotransplantation of human fetal thymic tissue and CD34+ cells. The potential use of these humanized mice in translational biomedical research is also discussed.
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页码：232 / 236
页数：4
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