Systemic Effects of TRAIL (TNF-Related Apoptosis-Inducing Ligand) during Acute γ-Irradiation

被引：0
作者：
E. N. Arkhipova
I. B. Alchinova
A. B. Cherepov
D. V. Rozanov
Yu. S. Medvedeva
M. Yu. Karganov
机构：
[1] Russian Academy of Medical Sciences,Research Institute of General Pathology and Pathophysiology
[2] Russian Academy of Medical Sciences,P. K. Anokhin Research Institute of Normal Physiology
[3] Oregon Health and Science University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 156卷
关键词：
radioresistance; TRAIL; apoptosis; mice;
D O I：
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中图分类号：
学科分类号：
摘要：
The effects of TRAIL at various physiological levels were studied on 101/Hf and C3H/Sn mice during acute γ-irradiation with 750 R. An intravenous injection of TRAIL attenuated the effects of γ-irradiation on the body weight, subfractions of blood plasma, horizontal and vertical activity in the open-field test, tissue injury in the small intestine and liver, and content of Hassall’s corpuscles in the thymus. The degree of these changes differed in mice of study strains.
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页码：452 / 456
页数：4
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