Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression

被引：0
|
作者：
Hyo-eun C Bhang
Kathleen L Gabrielson
John Laterra
Paul B Fisher
Martin G Pomper
机构：
[1] Johns Hopkins Medical Institutions,Department of Pharmacology and Molecular Sciences
[2] Johns Hopkins Medical Institutions,Department of Molecular and Comparative Pathobiology
[3] Johns Hopkins Medical Institutions,Department of Neurology
[4] Kennedy Krieger Institute,Department of Human and Molecular Genetics
[5] Virginia Commonwealth University Institute of Molecular Medicine,Russell H. Morgan Department of Radiology and Radiological Science
[6] Virginia Commonwealth University Massey Cancer Center,undefined
[7] Virginia Commonwealth University School of Medicine,undefined
[8] Johns Hopkins Medical Institutions,undefined
来源：
Nature Medicine | 2011年 / 17卷
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摘要：
Bhang and colleagues have developed a tumor-specific imaging strategy that uses the progression elevated gene-3 (PEG-3) promoter, known to be specifically associated with malignant transformation, to selectively drive the expression of luciferase or herpes simplex virus 1 thymidine kinase reporters. Systemic delivery of PEG-3 promoter–driven constructs using a nonviral gene delivery vehicle allowed detection of both primary tumors and micrometastatic disease in mouse models of human melanoma and breast cancer.
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页码：123 / 129
页数：6
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