Phase II/III weekly nab-paclitaxel plus gemcitabine or carboplatin versus gemcitabine/carboplatin as first-line treatment of patients with metastatic triple-negative breast cancer (the tnAcity study): study protocol for a randomized controlled trial

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作者
Denise A. Yardley
Adam Brufsky
Robert E. Coleman
Pierfranco F. Conte
Javier Cortes
Stefan Glück
Jean-Mark A. Nabholtz
Joyce O’Shaughnessy
Robert M. Beck
Amy Ko
Markus F. Renschler
Debora Barton
Nadia Harbeck
机构
[1] Sarah Cannon Research Institute and the Tennessee Oncology,Department of Surgery, Oncology and Gastroenterology
[2] PLLC,undefined
[3] University of Pittsburgh Medical Center,undefined
[4] Weston Park Hospital,undefined
[5] Sheffield Cancer Research Centre,undefined
[6] University of Padova,undefined
[7] Padova,undefined
[8] and Istituto Oncologico Veneto IRCCS,undefined
[9] Vall d’Hebron Institute of Oncology (VHIO),undefined
[10] Celgene Corporation,undefined
[11] Centre de Lutte Contre le Cancer d’Auvergne,undefined
[12] Texas Oncology-Baylor Charles A. Sammons Center; US Oncology,undefined
[13] Breast Center,undefined
[14] University of Munich,undefined
来源
Trials | / 16卷
关键词
tnAcity; Triple-negative breast cancer; Metastatic; -Paclitaxel; Abraxane; Gemcitabine; Carboplatin; Pick-the-winner trial design;
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[1]  
Liedtke C(2008)Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer J Clin Oncol 26 1275-81
[2]  
Mazouni C(2011)Triple-negative breast cancer: an unmet medical need Oncologist 16 1-11
[3]  
Hess KR(2007)Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California Cancer Registry Cancer 109 1721-8
[4]  
Andre F(2007)Triple-negative breast cancer: clinical features and patterns of recurrence Clin Cancer Res 13 4429-34
[5]  
Tordai A(2013)Updates in the treatment of basal/triple-negative breast cancer Curr Opin Obstet Gynecol 25 40-8
[6]  
Mejia JA(2008)Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases Cancer 113 2638-45
[7]  
Hudis CA(2005)Breast cancer molecular subtypes respond differently to preoperative chemotherapy Clin Cancer Res 11 5678-85
[8]  
Gianni L(2014)Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer J Clin Oncol 32 3840-7
[9]  
Bauer KR(2014)Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2-negative (or unknown) advanced breast cancer: American Society of Clinical Oncology Clinical Practice Guideline J Clin Oncol 32 3307-29
[10]  
Brown M(2014)ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2) Ann Oncol 25 1871-88