esBAF safeguards Stat3 binding to maintain pluripotency

被引：0
|
作者：
Noa Novershtern
Jacob H. Hanna
机构：
[1] The Weizmann Institute of Science,Noa Novershtern and Jacob H. Hanna are at The Department of Molecular Genetics
[2] Rehovot 76100,undefined
[3] Israel,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).
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页码：886 / 888
页数：2
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