Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma

被引：0
作者：
Yifei Zheng
Mingyue Zhu
Mengsen Li
机构：
[1] Hainan Medical College,Hainan Provincial Key Laboratory of Carcinogenesis and Intervention
[2] Hainan Medical College,Institution of Tumor
来源：
Journal of Cancer Research and Clinical Oncology | 2020年 / 146卷
关键词：
Hepatocellular carcinoma; Alpha-fetoprotein (AFP); Malignant transformation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for HCC, and up to 70% of HCC patients showed elevated serum levels of AFP. In the past two decades, evidences have shown that AFP not only is a tumorous biomarker for diagnosing HCC, but also plays a very complicated role in regulating proliferation, apoptosis, and autophagy and inhibiting the immune response of cells. Because AFP is significantly elevated during hepatocarcinogenesis, the role of AFP in the development of HCC is a scientific problem worthy of further exploration. In this review, we reviewed the effects of AFP on hepatocyte malignant transformation and the underlying mechanisms involved in the progression of HCC.
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页码：2439 / 2446
页数：7
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