Comparative modelling of protein structure and its impact on microbial cell factories

被引：0
作者：
Nuria B Centeno
Joan Planas-Iglesias
Baldomero Oliva
机构：
[1] Research Group on Biomedical Informatics (GRIB),Structural Bioinformatics Laboratory
[2] IMIM/UPF. c/ Dr. Aiguader 80.,undefined
来源：
Microbial Cell Factories | / 4卷
关键词：
Comparative Modeling; Loop Modeling; Protein Structure Prediction; Microbial Cell Factory; Determine Protein Structure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Comparative modeling is becoming an increasingly helpful technique in microbial cell factories as the knowledge of the three-dimensional structure of a protein would be an invaluable aid to solve problems on protein production. For this reason, an introduction to comparative modeling is presented, with special emphasis on the basic concepts, opportunities and challenges of protein structure prediction. This review is intended to serve as a guide for the biologist who has no special expertise and who is not involved in the determination of protein structure. Selected applications of comparative modeling in microbial cell factories are outlined, and the role of microbial cell factories in the structural genomics initiative is discussed.
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[1]  
Baneyx F(1999)Recombinant protein expression in Escherichia coli Curr Opin Biotechnol 10 411-421
[2]  
Baneyx F(2004)Recombinant protein folding and misfolding in Escherichia coli Nat Biotechnol 22 1399-1408
[3]  
Mujacic M(2004)Advances in the production of human therapeutic proteins in yeasts and filamentous fungi Nat Biotechnol 22 1409-1414
[4]  
Gerngross TU(1987)Knowledge-based prediction of protein structures and the design of novel molecules Nature 326 347-352
[5]  
Blundell TL(2000)Protein structure modeling for structural genomics Nat Struct Biol 7 986-990
[6]  
Sibanda BL(2000)Comparative protein structure modeling of genes and genomes Annu Rev Biophys Biomol Struct 29 291-325
[7]  
Sternberg MJ(1986)The relation between the divergence of sequence and structure in proteins Embo J 5 823-826
[8]  
Thornton JM(1980)How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins J Mol Biol 136 225-270
[9]  
Sanchez R(2004)Protein crystallization in the structural genomics era J Struct Funct Genomics 5 1-2
[10]  
Pieper U(2001)Protein structure prediction and structural genomics Science 294 93-96
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