Previous or Occult Hepatitis B Virus Infection in Hepatitis C Virus-Associated Hepatocellular Carcinoma Without Hepatic Fibrosis

被引：0
作者：
Shoji Kubo
Akihiro Tamori
Kazuki Ohba
Taichi Shuto
Takatsugu Yamamoto
Hiromu Tanaka
Shuhei Nishiguchi
Kenichi Wakasa
Kazuhiro Hirohashi
Hiroaki Kinoshita
机构：
[1] Osaka City University Medical School,Second Department of Surgery
[2] Osaka City University Medical School,Third Department of Internal Medicine
[3] Osaka City University Hospital,Department of Pathology
来源：
Digestive Diseases and Sciences | 2001年 / 46卷
关键词：
hepatocellular carcinoma; hepatitis C virus; hepatitis B virus; hepatitis B x DNA; hepatitis B x RNA; hepatic fibrosis;
D O I：
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中图分类号：
学科分类号：
摘要：
We investigated the role of hepatitis B virus infection in development of hepatocellular carcinoma in hepatitis C virus-infected patients without hepatic fibrosis. Of 253 patients, 8 lacked hepatic fibrosis (group 1); group 2 included the remaining 245 patients. Clinicopathologic findings were compared between the groups. Hepatitis B x gene was sought in cancers and adjoining noncancerous liver. Group 1 showed better liver function parameters and milder active hepatitis than group 2. The proportion of patients with anti-hepatitis B virus antibody tended to be higher in group 1 than in group 2. The proportion of patients with hepatitis B x RNA in cancers was significantly higher in group 1 than in group 2. All group 1 patients had previous or occult hepatitis B virus infection. Previous or occult hepatitis B virus infection may be critical in development of hepatocellular carcinomas in hepatitis C virus-infected patients without hepatic fibrosis.
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页码：2408 / 2414
页数：6
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