The role of FGF23 in CKD—with or without Klotho

被引：0
作者：
Hirotaka Komaba
Masafumi Fukagawa
机构：
[1] Endocrinology and Metabolism,Division of Nephrology
[2] Tokai University School of Medicine,undefined
来源：
Nature Reviews Nephrology | 2012年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fibroblast growth factor 23 (FGF23) is a hormone involved in bone and mineral metabolism. Increased FGF23 levels are associated with poor clinical outcomes in patients with kidney disease and could represent a novel biomarker and therapeutic target. In this article, Komaba and Fukagawa provide an overview of the physiological role of FGF23 and discuss the Klotho-dependent and Klotho-independent effects of FGF23 in disease.
引用
收藏
页码：484 / 490
页数：6
相关论文
共 131 条
[71]  
Vanrenterghem Y(2010)FGF23 fails to inhibit uremic parathyroid glands J. Am. Soc. Nephrol. 21 1125-1135
[72]  
Kestenbaum B(2010)Increased parathyroid expression of klotho in uremic rats Kidney Int. 78 1119-1127
[73]  
Menon V(2011)The secretory response of parathyroid hormone to acute hypocalcemia Kidney Int. 79 742-748
[74]  
Tonelli M(2010) is independent of parathyroid glandular sodium/potassium-ATPase activity Proc. Natl Acad. Sci. USA 107 407-412
[75]  
Koh N(2009)Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation J. Am. Soc. Nephrol. 20 388-396
[76]  
Fukagawa M(2011)Phosphorus binders and survival on hemodialysis J. Clin. Endocrinol. Metab. 96 E57-E64
[77]  
Kazama JJ(2003)Elevated FGF23 levels are associated with impaired calcium-mediated suppression of PTH in ESRD Nephrol. Dial. Transplant. 18 2613-2621
[78]  
Kazama JJ(2010)Relationship between parathyroid gland size and responsiveness to maxacalcitol therapy in patients with secondary hyperparathyroidism Clin. J. Am. Soc. Nephrol. 5 2305-2314
[79]  
Nakanishi S(2005)Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism J. Am. Soc. Nephrol. 16 1115-1125
[80]  
Nishi H(undefined)Activated injectable vitamin D and hemodialysis survival: a historical cohort study undefined undefined undefined-undefined
3456789101112