The role of FGF23 in CKD—with or without Klotho

被引：0
作者：
Hirotaka Komaba
Masafumi Fukagawa
机构：
[1] Endocrinology and Metabolism,Division of Nephrology
[2] Tokai University School of Medicine,undefined
来源：
Nature Reviews Nephrology | 2012年 / 8卷
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摘要：
Fibroblast growth factor 23 (FGF23) is a hormone involved in bone and mineral metabolism. Increased FGF23 levels are associated with poor clinical outcomes in patients with kidney disease and could represent a novel biomarker and therapeutic target. In this article, Komaba and Fukagawa provide an overview of the physiological role of FGF23 and discuss the Klotho-dependent and Klotho-independent effects of FGF23 in disease.
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页码：484 / 490
页数：6
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