Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β3 affinity modulation

被引:0
作者
A Goc
J Liu
T V Byzova
P R Somanath
机构
[1] Program in Clinical and Experimental Therapeutics,Department of Molecular Cardiology
[2] College of Pharmacy,Department of Medicine
[3] University of Georgia,undefined
[4] Georgia Health Sciences University,undefined
[5] HM1200,undefined
[6] Charlie Norwood VA Medical Center,undefined
[7] Cleveland Clinic,undefined
[8] Georgia Health Sciences University,undefined
来源
British Journal of Cancer | 2012年 / 107卷
关键词
prostate cancer; chemotaxis; invasion; bone matrix; Akt1; integrin ;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:713 / 723
页数:10
相关论文
共 234 条
[1]  
Briest F(2012)Tumor-stroma interactions in tumorigenesis: lessons from stem cell biology Front Biosci (Elite Ed) 4 1871-1887
[2]  
Berndt A(2005)Akt1 regulates pathological angiogenesis, vascular maturation and permeability Nat Med 11 1188-1196
[3]  
Clement J(2001)Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa Mol Cell 7 937-947
[4]  
Junker K(2009)Molecular mechanisms of metastasis in prostate cancer Asian J Androl 11 57-67
[5]  
Eggeling F(2002)The role of alpha(v)beta(3) in prostate cancer progression Neoplasia 4 191-194
[6]  
Grimm S(2005)Akt/PKB regulates actin organization and cell motility via Girdin/APE Dev Cell 9 389-402
[7]  
Friedrich K(2008)The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells J Cell Biol 183 1145-1157
[8]  
Chen J(2001)Integrins and prostate cancer metastases Cancer Metastasis Rev 20 321-331
[9]  
Somanath PR(1999)p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma J Clin Invest 103 321-329
[10]  
Razorenova O(2011)Metastasis: tumor cells becoming MENAcing Trends Cell Biol 21 81-90