The crosstalk between bone and fat in HIV-infected patients, with a focus on lipodystrophy

被引：0
作者：
Aoife G. Cotter
Patrick W. G. Mallon
机构：
[1] HIV Molecular Research Group, School of Medicine and Medical Science, University College Dublin, Dublin
[2] Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin
[3] Catherine McAuley Education and Research Centre, Mater Misericordiae University Hospital, Dublin 7, Eccles St.
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2012年 / 10卷 / 4期
关键词：
Adipokines; Adipose tissue; Body composition; Bone mineral density; Fat;
D O I：
10.1007/s12018-012-9135-9
中图分类号：
学科分类号：
摘要：
Low bone mineral density and osteoporosis are prevalent in cohorts of HIV-positive patients, with increased fracture rates also described. HIV is a disease characterised by abnormalities in body fat metabolism, particularly HIV-associated lipodystrophy, a common long-term side effect of antiretroviral therapy for HIV infection. Given the close metabolic relationships between bone and fat, the presence of these two conditions raises questions as to potential pathogenic links between the two. This review discusses both conditions and identifies potential factors that may link abnormalities in fat distribution with decreased bone mineral density. © 2012 Springer Science+Business Media, LLC.
引用
收藏
页码：266 / 276
页数：10
相关论文
共 122 条
[1]  
Carr A., Samaras K., Burton S., Law M., Freund J., Chisholm D.J., Cooper D.A., A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors, AIDS, 12, 7, (1998)
[2]  
Carr A., Miller J., Eisman J.A., Cooper D.A., Osteopenia in HIV-infected men: Association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy, AIDS, 15, 6, pp. 703-709, (2001)
[3]  
Guaraldi G., Ventura P., Albuzza M., Orlando G., Bedini A., Amorico G., Esposito R., Pathological fractures in AIDS patients with osteopenia and osteoporosis induced by antiretroviral therapy [8], AIDS, 15, 1, pp. 137-138, (2001)
[4]  
Huang J.S., Wilkie S.J., Sullivan M.P., Grinspoon S., Reduced bone density in androgen-deficient women with acquired immune deficiency syndrome wasting, Journal of Clinical Endocrinology and Metabolism, 86, 8, pp. 3533-3539, (2001)
[5]  
Zhao L.-J., Liu Y.-J., Liu P.-Y., Hamilton J., Recker R.R., Deng H.-W., Relationship of obesity with osteoporosis, Journal of Clinical Endocrinology and Metabolism, 92, 5, pp. 1640-1646, (2007)
[6]  
Fairfield W.P., Finkelstein J.S., Klibanski A., Grinspoon S.K., Osteopenia in eugonadal men with acquired immune deficiency syndrome wasting syndrome, Journal of Clinical Endocrinology and Metabolism, 86, 5, pp. 2020-2026, (2001)
[7]  
Huang J.S., Rietschel P., Hadigan C.M., Rosenthal D.I., Grinspoon S., Increased abdominal visceral fat is associated with reduced bone density in HIV-infected men with lipodystrophy, AIDS, 15, 8, pp. 975-982, (2001)
[8]  
Mallon P.W., Carr A., Cooper D.A., HIV-associated lipodystrophy: Description, pathogenesis, and molecular pathways, Curr Diab Rep, 2, 2, pp. 116-124, (2002)
[9]  
Palella Jr. F.J., Delaney K.M., Moorman A.C., Loveless M.O., Fuhrer J., Satten G.A., Aschman D.J., Holmberg S.D., Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection, New England Journal of Medicine, 338, 13, pp. 853-860, (1998)
[10]  
Carr A., Miller J., Matthew L., Cooper D.A., A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: Contribution to protease inhibitor-related lipodystrophy syndrome, AIDS, 14, 3, (2000)
12345678910