Analytical tools and current challenges in the modern era of neuroepigenomics

被引：0
作者：
Ian Maze
Li Shen
Bin Zhang
Benjamin A Garcia
Ningyi Shao
Amanda Mitchell
HaoSheng Sun
Schahram Akbarian
C David Allis
Eric J Nestler
机构：
[1] Icahn School of Medicine at Mount Sinai,Department of Pharmacology and Systems Therapeutics
[2] Icahn School of Medicine at Mount Sinai,Department of Neuroscience
[3] Icahn School of Medicine at Mount Sinai,Department of Genetics and Genomic Sciences
[4] Perelman School of Medicine,Department of Biochemistry and Biophysics
[5] University of Pennsylvania,Department of Psychiatry
[6] Icahn School of Medicine at Mount Sinai,undefined
[7] Laboratory of Chromatin Biology and Epigenetics,undefined
[8] The Rockefeller University,undefined
来源：
Nature Neuroscience | 2014年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this review, the authors discuss the applications of epigenomics approaches to studies of the CNS and critique the tools available to analyze neuroepigenomics data. They also assess the challenges of integrating these data with that of other approaches, such as transcriptomics, proteomics and behavior.
引用
收藏
页码：1476 / 1490
页数：14
相关论文
共 163 条
  • [71] Chen Y(2011)A statistical framework for modeling gene expression using chromatin features and application to modENCODE datasets Genome Biol. 12 R15-861
  • [72] Carroll TS(2012)Modeling gene expression using chromatin features in various cellular contexts Genome Biol. 13 R53-717
  • [73] Zhang Y(2009)The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain Science 324 929-35
  • [74] Heinz S(2009)BSMAP: whole genome bisulfite sequence MAPping program BMC Bioinformatics 10 232-933
  • [75] Shen L(2011)Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications Bioinformatics 27 1571-87
  • [76] Zhu LJ(2012)Analysing and interpreting DNA methylation data Nat. Rev. Genet. 13 705-386
  • [77] Liang K(2014)MOABS: model based analysis of bisulfite sequencing data Genome Biol. 15 R38-1028
  • [78] Keleş S(2008)A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis Nat. Biotechnol. 26 779-107
  • [79] Landt SG(2009)Common genetic variation and human traits N. Engl. J. Med. 360 1696-370
  • [80] Ernst J(2013)Mutational landscape and significance across 12 major cancer types Nature 502 333-1113
3456789101112