Analytical tools and current challenges in the modern era of neuroepigenomics

被引：0
作者：
Ian Maze
Li Shen
Bin Zhang
Benjamin A Garcia
Ningyi Shao
Amanda Mitchell
HaoSheng Sun
Schahram Akbarian
C David Allis
Eric J Nestler
机构：
[1] Icahn School of Medicine at Mount Sinai,Department of Pharmacology and Systems Therapeutics
[2] Icahn School of Medicine at Mount Sinai,Department of Neuroscience
[3] Icahn School of Medicine at Mount Sinai,Department of Genetics and Genomic Sciences
[4] Perelman School of Medicine,Department of Biochemistry and Biophysics
[5] University of Pennsylvania,Department of Psychiatry
[6] Icahn School of Medicine at Mount Sinai,undefined
[7] Laboratory of Chromatin Biology and Epigenetics,undefined
[8] The Rockefeller University,undefined
来源：
Nature Neuroscience | 2014年 / 17卷
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学科分类号：
摘要：
In this review, the authors discuss the applications of epigenomics approaches to studies of the CNS and critique the tools available to analyze neuroepigenomics data. They also assess the challenges of integrating these data with that of other approaches, such as transcriptomics, proteomics and behavior.
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页码：1476 / 1490
页数：14
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  • [1] Renthal W(2008)Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure J. Neurosci. 28 7344-7349
  • [2] Maze I(2010)Essential role of the histone methyltransferase G9a in cocaine-induced plasticity Science 327 213-216
  • [3] Visel A(2009)ChIP-seq accurately predicts tissue-specific activity of enhancers Nature 457 854-858
  • [4] Cheung I(2010)Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex Proc. Natl. Acad. Sci. USA 107 8824-8829
  • [5] Peleg S(2010)Altered histone acetylation is associated with age-dependent memory impairment in mice Science 328 753-756
  • [6] Guo JU(2011)Neuronal activity modifies the DNA methylation landscape in the adult brain Nat. Neurosci. 14 1345-1351
  • [7] Maze I(2011)Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens Proc. Natl. Acad. Sci. USA 108 3035-3040
  • [8] Szulwach KE(2011)5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging Nat. Neurosci. 14 1607-1616
  • [9] Zhou Z(2011)Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol Proc. Natl. Acad. Sci. USA 108 6626-6631
  • [10] Hunter RG(2012)Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response Proc. Natl. Acad. Sci. USA 109 17657-17662
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