Commentary: Current Perspectives on the Aggregation of Protein Drugs

[1] Shi S(2012)Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA J Pharm Sci 101 1969-84

[2] Liu J(2012)Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements J Pharm Sci 101 1701-20

[3] Joshi SB(2012)Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags J Pharm Sci 101 3636-50

[4] Krasnoperov V(2011)Comparability assessments of process and product changes made during development of two different monoclonal antibodies Biologicals 39 9-22

[5] Gill P(2012)An empirical phase diagram approach to investigate conformational stability of “second-generation” functional mutants of acidic fibroblast growth factor-1 Protein Sci 21 418-32

[6] Middaugh CR(2014)High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability AAPS J 16 48-64

[7] Cheng W(2003)Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life J Pharm Sci 92 1095-111

[8] Joshi SB(2012)Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody J Pharm Sci 101 1678-87

[9] He F(2013)Non-Arrhenius protein aggregation AAPS J 15 840-51

[10] Brems DN(2012)Slip flow in colloidal crystals for ultraefficient chromatography J Am Chem Soc 134 10780-2

[1] Shi S(2012)Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA J Pharm Sci 101 1969-84

[2] Liu J(2012)Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements J Pharm Sci 101 1701-20

[3] Joshi SB(2012)Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags J Pharm Sci 101 3636-50

[4] Krasnoperov V(2011)Comparability assessments of process and product changes made during development of two different monoclonal antibodies Biologicals 39 9-22

[5] Gill P(2012)An empirical phase diagram approach to investigate conformational stability of “second-generation” functional mutants of acidic fibroblast growth factor-1 Protein Sci 21 418-32

[6] Middaugh CR(2014)High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability AAPS J 16 48-64

[7] Cheng W(2003)Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life J Pharm Sci 92 1095-111

[8] Joshi SB(2012)Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody J Pharm Sci 101 1678-87

[9] He F(2013)Non-Arrhenius protein aggregation AAPS J 15 840-51

[10] Brems DN(2012)Slip flow in colloidal crystals for ultraefficient chromatography J Am Chem Soc 134 10780-2