Paternal Age and Epilepsy in the Offspring

被引：0
作者：
Mogens Vestergaard
Alissa Mork
Kreesten M. Madsen
Jørn Olsen
机构：
[1] University of Aarhus,The Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology
[2] University of Minnesota School of Public Health,Division of Environmental and Occupational Health
[3] UCLA School of Public Health,Department of Epidemiology
[4] University of Aarhus,Institute of Public Health, Department of Epidemiology
来源：
European Journal of Epidemiology | 2005年 / 20卷
关键词：
de novo mutations; epidemiology; epilepsy; paternal age;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25–29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.
引用
收藏
页码：1003 / 1005
页数：2
相关论文
共 36 条
  • [1] Sipos A(2004)Paternal age and schizophrenia: A population based cohort study BMJ 329 1070-723
  • [2] Rasmussen F(2004)Parental age, family size, and risk of multiple sclerosis Epidemiology 15 717-46
  • [3] Harrison G(1993)Parental age, genetic mutation, and cerebral palsy J Med Genet 30 44-971
  • [4] Montgomery SM(2005)Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study J Child Psychol Psychiatry 46 963-125
  • [5] Lambe M(2005)Paternal age and intelligence: Implications for age-related genomic changes in male germ cells Psychiatr Genet 15 117-47
  • [6] Olsson T(2000)The origins, patterns and implications of human spontaneous mutation Nat Rev Genet 1 40-178
  • [7] Ekbom A(2001)Genetic and environmental factors in epilepsy: A population-based study of 11900 Danish twin pairs Epilepsy Res 44 167-1332
  • [8] Fletcher NA(2001)De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy Am J Hum Genet 68 1327-225
  • [9] Foley J(1998)The Danish fertility database Dan Med Bull 45 221-268
  • [10] Lauritsen MB(1999)The Danish national hospital register. A valuable source of data for modern health sciences Dan Med Bull 46 263-596
1234