Advances in therapeutics for chronic hepatitis B

被引：0
作者：
Ninghan Yang
Antonio Bertoletti
机构：
[1] Agency for Science,Viral Hepatitis Laboratory, Singapore Institute of Clinical Sciences (SICS)
[2] Technology and Research (A*STAR),Emerging Infectious Disease (EID) Program
[3] Duke-NUS Graduate Medical School,undefined
来源：
Hepatology International | 2016年 / 10卷
关键词：
Chronic hepatitis B; Hepatitis B virus; Viral replication; Antiviral drugs; Immunity; Immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chronic hepatitis B infection remains a major disease burden globally, and leads to high risk of hepatocellular carcinoma development. Current therapies of nucleot(s)ide analogues and interferon alpha treatment remain limited in their efficacy. Several key findings in the hepatitis B virus (HBV) life cycle have led to the development of novel antiviral drugs to inhibit viral replication and persistence. In addition, recent studies on HBV-specific innate and adaptive immune responses have advanced development of immunotherapy to restore immune mediated virus control in chronic hepatitis B patients. In this review, we discuss potential new therapeutic strategies targeting HBV or the host immune system that might lead to a sustained cure for chronic hepatitis B.
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页码：277 / 285
页数：8
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