Interaction between the keratin cytoskeleton and eEF1Bγ affects protein synthesis in epithelial cells

被引：0
|
作者：
Seyun Kim
Juliane Kellner
Chang-Hun Lee
Pierre A Coulombe
机构：
[1] The Johns Hopkins University School of Medicine,Department of Biological Chemistry
[2] The Johns Hopkins University School of Medicine,Department of Dermatology
来源：
Nature Structural & Molecular Biology | 2007年 / 14卷
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摘要：
Eukaryotic elongation factor-1 (eEF1) is essential for peptide-chain elongation during translation. We report that its γ subunit (eEF1Bγ) specifically binds, and bundles, keratin intermediate filaments. Disrupting this interaction depresses translation by ∼20% and selectively increases 80S ribosomes in epithelial cells, an outcome recapitulated by RNA interference–mediated silencing of eEF1Bγ. These findings extend the emerging relationship between keratin proteins and the translational machinery.
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页码：982 / 983
页数：1
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