Normal QT dispersion in colchicine-resistant familial Mediterranean fever (FMF)

被引：0
作者：
Udi Nussinovitch
Avi Livneh
Benjamin Volovitz
Moshe Nussinovitch
Ilan Ben-Zvi
Merav Lidar
Naomi Nussinovitch
机构：
[1] Israel Naval Medical Institute,The Heller Institute of Medical Research, and Department of Medicine F
[2] IDF Medical Corps,Sackler Faculty of Medicine
[3] Sheba Medical Center,Department of Pediatrics C
[4] Tel Aviv University,Hypertension Unit and Department of Internal Medicine D
[5] Schneider Children’s Medical Center of Israel,undefined
[6] Sheba Medical Center,undefined
来源：
Clinical Rheumatology | 2012年 / 31卷
关键词：
Arrhythmia; Atherosclerosis; Familial Mediterranean fever; QT dispersion (QTd);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The association between familial Mediterranean fever (FMF) and subclinical cardiac disease remains controversial. The aim of the current study was to evaluate whether FMF patients, who do not respond to colchicine treatment, and thereby endure persistent inflammation, have increased QT dispersion (QTd) values. Twenty-two FMF patients and 22 age- and sex-matched control subjects were included in the study. Repolarization and QT dispersion parameters were computed from 12-lead ECG recording using designated computer software, and results of five beats were subsequently averaged. Both FMF patients and controls had similar comorbidities, similar values of average QT, average corrected QT interval length, average QTd interval, average QT corrected dispersion, QT dispersion ratio, JT dispersion (JTd), and JT corrected dispersion. In conclusion, FMF patients who were unresponsive to colchicine treatment and did not develop amyloidosis had normal QTd and JTd parameters, indicating a non-increased risk for repolarization-associated ventricular arrhythmias.
引用
收藏
页码：1093 / 1096
页数：3
相关论文
共 121 条
  • [1] Padeh S(2010)Familial Mediterranean fever in children presenting with attacks of fever alone J Rheumatol 37 865-869
  • [2] Livneh A(1997)Criteria for the diagnosis of familial Mediterranean fever Arthritis Rheum 40 1879-1885
  • [3] Pras E(2007)Early ultrasonographic markers of atherosclerosis in patients with familial Mediterranean fever Clin Rheumatol 26 1467-1473
  • [4] Shinar Y(2006)Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF J Am Coll Cardiol 48 2351-2353
  • [5] Lidar M(2004)Cardiovascular reactivity score for the assessment of dysautonomia in familial Mediterranean fever Rheumatol Int 24 147-152
  • [6] Feld O(2011)Heart rate variability in familial Mediterranean fever Rheumatol Int 31 39-43
  • [7] Berkun Y(2009)Assessment of atrial conduction time in patients with familial Mediterranean fever Pacing Clin Electrophysiol 32 308-313
  • [8] Livneh A(2011)P wave dispersion in familial Mediterranean fever Rheumatol Int 31 1591-1594
  • [9] Langevitz P(2009)QT dispersion and transmural dispersion of repolarization in patients with familial Mediterranean fever Mod Rheumatol 19 550-555
  • [10] Zemer D(2010)QT dispersion in uncomplicated familial Mediterranean fever Clin Rheumatol 29 1353-1356
12345678910