The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: a meta-analysis update

被引：0
作者：
Young Ho Lee
Hye-Soon Lee
Sung Jae Choi
Jong Dae Ji
Gwan Gyu Song
机构：
[1] Korea University Anam Hospital,Division of Rheumatology, Department of Internal Medicine
[2] Korea University College of Medicine,Division of Rheumatology, Department of Internal Medicine
[3] Hanyang University Medical Center,undefined
来源：
Molecular Biology Reports | 2012年 / 39卷
关键词：
Mannose-binding lectin; Polymorphism; Systemic lupus erythematosus; Meta-analysis;
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摘要：
The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154–1.459, P = 1.4 × 10−5]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062–1.462, P = 0.007; OR = 1.268, 95% CI = 1.049–1.532, P = 0.014; OR = 1.939, 95% CI = 1.269–2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
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页码：5569 / 5574
页数：5
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