New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity

被引：0
作者：
Andrei V. Bogdanov
Al’bina M. Vazykhova
Nadezhda R. Khasiyatullina
Dmitry B. Krivolapov
Alexey B. Dobrynin
Alexandra D. Voloshina
Vladimir F. Mironov
机构：
[1] Russian Academy of Sciences,A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
来源：
Chemistry of Heterocyclic Compounds | 2016年 / 52卷
关键词：
isatin; piperazines; aminomethylation; antimicrobial activity; Mannich reaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
[graphic not available: see fulltext] A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.
引用
收藏
页码：25 / 30
页数：5
相关论文
共 50 条
  • [31] Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives
    Sumitra Nain
    Garima Mathur
    Tulika Anthwal
    Swapnil Sharma
    Sarvesh Paliwal
    Pharmaceutical Chemistry Journal, 2023, 57 : 196 - 203
  • [32] New piperazine and morpholine derivatives: Mass spectrometry characterization and evaluation of their antimicrobial activity
    Acquavia, Maria Assunta
    Bonomo, Maria Grazia
    Bianco, Giuliana
    Salzano, Giovanni
    Gaeta, Carmine
    Iannece, Patrizia
    Di Capua, Angela
    Giuzio, Federica
    Saturnino, Carmela
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 246
  • [33] Synthesis, characterization and in vitro antimicrobial activity of some novel 5-substituted Schiff and Mannich base of isatin derivatives
    Prakash, Chinnasamy Rajaram
    Raja, Sundararajan
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2013, 17 (03) : 337 - 344
  • [34] Synthesis and antimicrobial activity of some new Mannich bases, N-(2-hydroxy-1-naphthyl)amino acid, methyl ester and hydrazide derivatives
    Hassan, HM
    Shedid, SAM
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 1998, 63 (02) : 125 - 130
  • [35] Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases
    Marinescu, Maria
    Cinteza, Ludmila Otilia
    Marton, George Iuliu
    Chifiriuc, Mariana-Carmen
    Popa, Marcela
    Stanculescu, Ioana
    Zlaru, Christina-Marie
    Stavarache, Cristina-Elena
    BMC CHEMISTRY, 2020, 14 (01)
  • [36] Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases
    Maria Marinescu
    Ludmila Otilia Cinteză
    George Iuliu Marton
    Mariana-Carmen Chifiriuc
    Marcela Popa
    Ioana Stănculescu
    Christina-Marie Zălaru
    Cristina-Elena Stavarache
    BMC Chemistry, 14
  • [37] Synthesis and antimicrobial activity of fused isatin and diazepine derivatives derived from 2-acetyl benzofuran
    Kenchappa, R.
    Bodke, Y. D.
    Telkar, S.
    Nagaraja, O.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (09) : 2027 - 2038
  • [38] Synthesis, characterization and antimicrobial activity of Mannich bases of 2-chloro-4-nitrobenzamide derived from sulphonamides
    Joshi, Sheela
    Das Manikpuri, Anju
    Khare, Deepak
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2008, 85 (05) : 508 - 512
  • [39] Synthesis and antimicrobial activity of fused isatin and diazepine derivatives derived from 2-acetyl benzofuran
    R. Kenchappa
    Y. D. Bodke
    S. Telkar
    O. Nagaraja
    Russian Journal of General Chemistry, 2017, 87 : 2027 - 2038
  • [40] Synthesis and Antimicrobial Activity of Cyclohexane-Containing Mannich Bases Derived from Secondary Amines
    Mammadbayli, E. H.
    Ismayilova, S. V.
    Hajiyeva, G. A.
    Jafarova, N. A.
    Suleymanova, E. I.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (10) : 1423 - 1428
12345