New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity

被引：0
作者：
Andrei V. Bogdanov
Al’bina M. Vazykhova
Nadezhda R. Khasiyatullina
Dmitry B. Krivolapov
Alexey B. Dobrynin
Alexandra D. Voloshina
Vladimir F. Mironov
机构：
[1] Russian Academy of Sciences,A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
来源：
Chemistry of Heterocyclic Compounds | 2016年 / 52卷
关键词：
isatin; piperazines; aminomethylation; antimicrobial activity; Mannich reaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
[graphic not available: see fulltext] A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.
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页码：25 / 30
页数：5
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