New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity

被引：0
作者：
Andrei V. Bogdanov
Al’bina M. Vazykhova
Nadezhda R. Khasiyatullina
Dmitry B. Krivolapov
Alexey B. Dobrynin
Alexandra D. Voloshina
Vladimir F. Mironov
机构：
[1] Russian Academy of Sciences,A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
来源：
Chemistry of Heterocyclic Compounds | 2016年 / 52卷
关键词：
isatin; piperazines; aminomethylation; antimicrobial activity; Mannich reaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
[graphic not available: see fulltext] A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.
引用
收藏
页码：25 / 30
页数：5
相关论文
共 50 条
  • [1] New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity
    Bogdanov, Andrei V.
    Vazykhova, Al'bina M.
    Khasiyatullina, Nadezhda R.
    Krivolapov, Dmitry B.
    Dobrynin, Alexey B.
    Voloshina, Alexandra D.
    Mironov, Vladimir F.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2016, 52 (01) : 25 - 30
  • [2] Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives
    Pandeya, SN
    Yogeeswari, P
    Sriram, D
    de Clercq, E
    Pannecouque, C
    Witvrouw, M
    CHEMOTHERAPY, 1999, 45 (03) : 192 - 196
  • [3] Synthesis and Antimicrobial Activity of New Mannich Bases with Piperazine Moiety
    Janowska, Sara
    Andrzejczuk, Sylwia
    Gawrys, Piotr
    Wujec, Monika
    MOLECULES, 2023, 28 (14):
  • [4] Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine
    Pandeya, SN
    Sriram, D
    Nath, G
    De Clercq, E
    FARMACO, 1999, 54 (09): : 624 - 628
  • [5] A Study on Hydrolytic Stability of Isatin N-Mannich Bases
    Orlova, D. D.
    Novikova, D. S.
    Garabadzhiu, A. V.
    Tribulovich, V. G.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (01) : 48 - 56
  • [6] A Study on Hydrolytic Stability of Isatin N-Mannich Bases
    D. D. Orlova
    D. S. Novikova
    A. V. Garabadzhiu
    V. G. Tribulovich
    Russian Journal of General Chemistry, 2018, 88 : 48 - 56
  • [7] A convenient synthetic route from isatin N-Mannich bases to nitrogen-containing derivatives of isoindigo
    Bogdanov, Andrei V.
    Mironov, Vladimir F.
    Musin, Lenar I.
    Musin, Rashid Z.
    Krivolapov, Dmitry B.
    Litvinov, Igor A.
    MONATSHEFTE FUR CHEMIE, 2011, 142 (01): : 81 - 85
  • [8] A convenient synthetic route from isatin N-Mannich bases to nitrogen-containing derivatives of isoindigo
    Andrei V. Bogdanov
    Vladimir F. Mironov
    Lenar I. Musin
    Rashid Z. Musin
    Dmitry B. Krivolapov
    Igor A. Litvinov
    Monatshefte für Chemie - Chemical Monthly, 2011, 142 : 81 - 85
  • [9] Synthesis, anticonvulsant and antimicrobial activities of novel mannich bases of isatin derivatives
    Aanandhi, M. Vijey
    Vaidhyalingam, V.
    George, Shiny
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (06) : 4588 - 4594
  • [10] Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases
    Shah, T. B.
    Gupte, A.
    Patel, M. R.
    Chaudhari, V. S.
    Patel, H.
    Patel, V. C.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (01): : 88 - 96
12345