Assessment of process configurations to combine enantioselective chromatography with enzymatic racemization

被引：0
作者：
Isabel Harriehausen
Katarzyna Wrzosek
Heike Lorenz
Andreas Seidel-Morgenstern
机构：
[1] Max-Planck-Institut fur Dynamik komplexer technischer Systeme,
来源：
Adsorption | 2020年 / 26卷
关键词：
Chiral separation; Batch chromatography; SMB processes; Enzymatic racemization; Distomer recovery; Process integration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Enantioselective chromatography is nowadays a reliable tool for single enantiomer production from a racemate. The recovery of the distomer by racemization and recycling is a promising method to tackle the 50% yield constraint and to increase the productivity. In this paper three process configurations are compared. The production of enantiopure mandelic acid and methionine enantiomers exploiting different enzymes for racemization are evaluated as part of different chromatographic process configurations. First, the benefits of conventional simulated moving bed (SMB) chromatography in contrast to a single column batch separation unit are assessed in integrated configurations. Then, a concept of coupling the racemization with a simpler three-zone SMB unit, where one regeneration zone is removed, is evaluated.
引用
收藏
页码：1199 / 1213
页数：14
相关论文
共 85 条
  • [1] Bechtold M(2006)Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals J. Biotechnol. 124 146-162
  • [2] Makart S(2016)Exploiting racemases Appl. Microbiol. Biotechnol. 100 7423-7436
  • [3] Heinemann M(2001)Covalently bonded polysaccharide derivatives as chiral stationary phases in high-performance liquid chromatography J. Chromatogr. A 906 155-170
  • [4] Panke S(2001)Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers J. Chromatogr. A 906 379-397
  • [5] Femmer C(2014)Model-based identification of optimal operating conditions for amino acid simulated moving bed enantioseparation using a macrocyclic glycopeptide stationary phase J. Chromatogr. A 1346 34-42
  • [6] Bechtold M(2016)Integration of simulated moving bed chromatography and enzymatic racemization for the production of single enantiomers Chem. Eng. Sci. 152 649-662
  • [7] Roberts TM(1983)A new process combining adsorption and enzyme reaction for producing higher-fructose syrup Biotechnol. Bioeng. 25 2371-2393
  • [8] Panke S(2010)A thermodynamically consistent explicit competitive adsorption isotherm model based on second-order single component behaviour J. Chromatogr. A 1217 2132-2137
  • [9] Franco P(2014)Processes to separate enantiomers Angew. Chem. Int. Ed. 53 1218-1250
  • [10] Senso A(2007)Dynamic kinetic resolution catalyzed by enzymes and metals Curr. Opin. Chem. Biol. 11 226-232
123456789