Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma

被引：0
作者：
Frank B. Furnari
Timothy F. Cloughesy
Webster K. Cavenee
Paul S. Mischel
机构：
[1] University of California San Diego,Ludwig Institute for Cancer Research and the Department of Pathology
[2] David Geffen School of Medicine,Department of Neurology
[3] University of California,Ludwig Institute for Cancer Research and the Department of Medicine
[4] University of California San Diego,undefined
来源：
Nature Reviews Cancer | 2015年 / 15卷
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学科分类号：
摘要：
Heterogeneous expression of the epidermal growth factor receptor (EGFR) in glioblastoma poses an important challenge for the effective use of EGFR-targeted therapies. In this Opinion article, Furnariet al. highlight the possible mechanisms underlying EGFR heterogeneity, and the importance in understanding these mechanisms to improve treatment outcome in glioblastoma.
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页码：302 / 310
页数：8
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