Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?

被引：0
作者：
Stefan Löb
Alfred Königsrainer
Hans-Georg Rammensee
Gerhard Opelz
Peter Terness
机构：
[1] Visceral and Transplant Surgery,Stefan Löb and Alfred Königsrainer are at the Department of General
[2] University Hospital of Tubingen,Department of Immunology
[3] Hoppe-Seyler-Strasse 3,Department of Transplantation Immunology
[4] 72076 Tubingen,undefined
[5] Germany.,undefined
[6] Hans-Georg Rammensee is at the Institute of Cell Biology,undefined
[7] University of Tubingen,undefined
[8] Auf der Morgenstelle 15,undefined
[9] 72076 Tubingen,undefined
[10] Germany.,undefined
[11] Gerhard Opelz and Peter Terness are at the Institute of Immunology,undefined
[12] University of Heidelberg,undefined
[13] INF-305,undefined
[14] 69120 Heidelberg,undefined
[15] Germany.,undefined
来源：
Nature Reviews Cancer | 2009年 / 9卷
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摘要：
Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme that is expressed in tumours and enables them to escape immunologically mediated rejection. However, we are far from understanding the biological relevance of IDO expression during tumorigenesis. We need a better understanding of IDO biology to provide a rationale for the use of IDO inhibitors in the clinic.
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页码：445 / 452
页数：7
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