Roxadustat alleviates the inflammatory status in patients receiving maintenance hemodialysis with erythropoiesis-stimulating agent resistance by increasing the short-chain fatty acids producing gut bacteria

[1] Nakhoul G(2016)Anemia of chronic kidney disease: treat it, but not too aggressively Clevel Clin J Med 83 613-624

[2] Simon JF(2012)Mechanisms of anemia in CKD J Am Soc Nephrol 23 1631-1634

[3] Babitt JLLH(2010)Erythropoiesis stimulatory agent- resistant anemia in dialysis patients: review of causes and management Blood Purif 29 1-12

[4] Kanbay M(2018)Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease Expert Opin Investig Drugs 27 613-621

[5] Perazella MA(2017)Targeting hypoxia-inducible factors for the treatment of anemia in chronic kidney disease patients Am J Nephrol 45 187-199

[6] Kasapoglu B(2008)Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol Cell 30 393-402

[7] Del VL(2004)Hypoxia-inducible factor (HIF-1) alpha: its protein stability and biological functions Exp Mol Med 36 1-12

[8] Locatelli F(2015)Activation of HIF-1α and LL-37 by commensal bacteria inhibits Nat Med 21 808-814

[9] Locatelli F(2020) colonization Cell Metab 31 115-130

[10] Fishbane S(2018)Microbial metabolite signaling is required for systemic iron homeostasis J Orthop Surg 26 920440156-164

[1] Nakhoul G(2016)Anemia of chronic kidney disease: treat it, but not too aggressively Clevel Clin J Med 83 613-624

[2] Simon JF(2012)Mechanisms of anemia in CKD J Am Soc Nephrol 23 1631-1634

[3] Babitt JLLH(2010)Erythropoiesis stimulatory agent- resistant anemia in dialysis patients: review of causes and management Blood Purif 29 1-12

[4] Kanbay M(2018)Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease Expert Opin Investig Drugs 27 613-621

[5] Perazella MA(2017)Targeting hypoxia-inducible factors for the treatment of anemia in chronic kidney disease patients Am J Nephrol 45 187-199

[6] Kasapoglu B(2008)Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol Cell 30 393-402

[7] Del VL(2004)Hypoxia-inducible factor (HIF-1) alpha: its protein stability and biological functions Exp Mol Med 36 1-12

[8] Locatelli F(2015)Activation of HIF-1α and LL-37 by commensal bacteria inhibits Nat Med 21 808-814

[9] Locatelli F(2020) colonization Cell Metab 31 115-130

[10] Fishbane S(2018)Microbial metabolite signaling is required for systemic iron homeostasis J Orthop Surg 26 920440156-164