The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody1

被引：0
|
作者：
James D. Andya
Yuh-Fun Maa
Henry R. Costantino
Phuong-Anh Nguyen
Nancy Dasovich
Theresa D. Sweeney
Chung C. Hsu
Steven J. Shire
机构：
[1] Genentech,Pharmaceutical Research and Development
[2] Inc.,undefined
[3] Powderject Technologies,undefined
[4] Alkermes,undefined
[5] Inc.,undefined
来源：
Pharmaceutical Research | 1999年 / 16卷
关键词：
aggregation; glycation; fine particle fraction; protein formulation; protein stability; spray drying;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized monoclonal antibody.
引用
收藏
页码：350 / 358
页数：8
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