Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats

[1] Buerkle H(1998)Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat Br J Anaesth 81 208-215

[2] Yaksh TL(2003)The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit J Intensive Care Med 18 29-41

[3] Martin E(2004)Dexmedetomidine as a total intravenous anesthetic agent Anesthesiology 101 787-790

[4] Ramsay G(2000)The effects of increasing plasma concentrations of dexmedetomidine in humans Anesthesiology 93 382-394

[5] Mantz J(2010)Visual P2–N2 complex and arousal at the time of encoding predict the time domain characteristics of amnesia for multiple intravenous anesthetic drugs in humans Anesthesiology 113 313-326

[6] Sum-Ping ST(2012)Event-related functional magnetic resonance imaging of a low dose of dexmedetomidine that impairs long-term memory Anesthesiology 117 981-995

[7] Ramsay MA(1993)A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 31-39

[8] Luterman DL(2008)Dexmedetomidine reduces long-term potentiation in mouse hippocampus Anesthesiology 108 94-102

[9] Ebert TJ(2011)Long-lasting effects of neonatal pentobarbital administration on spatial learning and hippocampal synaptic plasticity Brain Res 1388 69-76

[10] Hall JE(2007)Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo Anesth Analg 105 1006-1011

[1] Buerkle H(1998)Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat Br J Anaesth 81 208-215

[2] Yaksh TL(2003)The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit J Intensive Care Med 18 29-41

[3] Martin E(2004)Dexmedetomidine as a total intravenous anesthetic agent Anesthesiology 101 787-790

[4] Ramsay G(2000)The effects of increasing plasma concentrations of dexmedetomidine in humans Anesthesiology 93 382-394

[5] Mantz J(2010)Visual P2–N2 complex and arousal at the time of encoding predict the time domain characteristics of amnesia for multiple intravenous anesthetic drugs in humans Anesthesiology 113 313-326

[6] Sum-Ping ST(2012)Event-related functional magnetic resonance imaging of a low dose of dexmedetomidine that impairs long-term memory Anesthesiology 117 981-995

[7] Ramsay MA(1993)A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 31-39

[8] Luterman DL(2008)Dexmedetomidine reduces long-term potentiation in mouse hippocampus Anesthesiology 108 94-102

[9] Ebert TJ(2011)Long-lasting effects of neonatal pentobarbital administration on spatial learning and hippocampal synaptic plasticity Brain Res 1388 69-76

[10] Hall JE(2007)Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo Anesth Analg 105 1006-1011