Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

被引:0
作者
Essam M. Hussein
Munirah M. Al-Rooqi
Shimaa M. Abd El-Galil
Saleh A. Ahmed
机构
[1] Umm Al-Qura University,Department of Chemistry, Faculty of Applied Science
[2] Assiut University,Chemistry Department, Faculty of Science
[3] Al-azhar University,Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls)
来源
BMC Chemistry | / 13卷
关键词
Sulfonamide; Anticancer; Antimicrobial; Acetamides; Molecular docking; Structure–activity relationship (SAR); DHFR inhibitors;
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  • [41] Noaman E(2017)-(6-Arylbenzo[d]thiazole-2-acetamide derivatives and their biological activities: an experimental and computational approach Chem Heterocycl Comp 53 1148-1155
  • [42] Ghorab MM(2011)Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Arkivoc 10 85-98
  • [43] Alqasoumi SI(2014) dUTP nucleotidohydrolase Russ J Bioorg Chem 40 343-349
  • [44] Al-Taweel AM(2015)Discovery of novel 2- Chem Cent J 9 25-795
  • [45] Alafeefy AM(2015)-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities Z Naturforsch 70b 783-437
  • [46] Ghorab MM(2016)Exploring the molecular mechanism of dihydrofolate reductase SpringerPlus 5 887-1110
  • [47] Noaman E(1982)Dihydrofolate reductase inhibitors as antibacterial agents Experientia 38 436-265
  • [48] Ghorab MM(1999)Design, synthesis and anticancer evaluation of novel tetrahydroquinoline derivatives containing sulfonamide moiety Bioorg Med Chem 7 1105-901
  • [49] Ragab FA(2017)Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety Eur J Med Chem 129 251-171
  • [50] Heiba HI(2008)Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives Proteins 73 889-1572