Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

[1] Drews J(2000)Drug discovery: a historical perspective Science 287 1960-1964

[2] Krátký M(2012)Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxy-benzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold Eur J Med Chem 50 433-440

[3] Vinsová J(1980)Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport Biochem Pharmacol 29 1879-1882

[4] Volková M(1979)Isosterism and molecular modification in drug design Chem Soc Rev 8 563-580

[5] Buchta V(2000)Carbonic anhydrase inhibitors and their therapeutic potential Expert Opin Ther Pat 10 575-600

[6] Trejtnar F(2004)Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene-sulfonamides: a molecular connectivity approach Bioorg Med Chem Lett 14 5661-5666

[7] Stolaríková J(2002)Sulfonamides and sulfonylated derivatives as anticancer agents Curr Cancer Drug Targ 2 55-75

[8] Anjaneyulu R(2004)Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and trans-membrane, tumor-associated isozyme IX Bioorg Med Chem Lett 14 217-223

[9] Anjaneyulu K(2006)Novel synthesis of pyrrolo[2,3-d]pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents Arzneim Forsch 56 301-308

[10] Couturier E(2010)Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]Benzenesulfonamides Eur J Med Chem 45 3011-3018

[1] Drews J(2000)Drug discovery: a historical perspective Science 287 1960-1964

[2] Krátký M(2012)Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxy-benzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold Eur J Med Chem 50 433-440

[3] Vinsová J(1980)Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport Biochem Pharmacol 29 1879-1882

[4] Volková M(1979)Isosterism and molecular modification in drug design Chem Soc Rev 8 563-580

[5] Buchta V(2000)Carbonic anhydrase inhibitors and their therapeutic potential Expert Opin Ther Pat 10 575-600

[6] Trejtnar F(2004)Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene-sulfonamides: a molecular connectivity approach Bioorg Med Chem Lett 14 5661-5666

[7] Stolaríková J(2002)Sulfonamides and sulfonylated derivatives as anticancer agents Curr Cancer Drug Targ 2 55-75

[8] Anjaneyulu R(2004)Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and trans-membrane, tumor-associated isozyme IX Bioorg Med Chem Lett 14 217-223

[9] Anjaneyulu K(2006)Novel synthesis of pyrrolo[2,3-d]pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents Arzneim Forsch 56 301-308

[10] Couturier E(2010)Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]Benzenesulfonamides Eur J Med Chem 45 3011-3018