Resistance to high-fat-diet-induced obesity and sexual dimorphism in the metabolic responses of transgenic mice with moderate uncoupling protein 3 overexpression in glycolytic skeletal muscles

被引:0
作者
C. Tiraby
G. Tavernier
F. Capel
A. Mairal
F. Crampes
J. Rami
C. Pujol
J. A. Boutin
D. Langin
机构
[1] Institut de Médecine Moléculaire de Rangueil,Inserm U858, Laboratoire de recherches sur les obésités
[2] Université Paul Sabatier,Institut Louis Bugnard
[3] Institut Fédératif de Biologie de Purpan,CHU de Toulouse, Laboratoire de biochimie
[4] Institut de Recherches Servier,Division de Pharmacologie Moléculaire et Cellulaire
来源
Diabetologia | 2007年 / 50卷
关键词
Glucose tolerance; Glycolytic skeletal muscle; High-fat diet; Metabolic flexibility; Mouse; Obesity; Sexual dimorphism; UCP3; Uncoupling;
D O I
暂无
中图分类号
学科分类号
摘要
引用
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页码:2190 / 2199
页数:9
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[1]  
Lowell BB(2005)Mitochondrial dysfunction and type 2 diabetes Science 307 384-387
[2]  
Shulman GI(2000)The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP Biochem J 345 161-179
[3]  
Ricquier D(2005)The mitochondrial uncoupling-protein homologues Nat Rev Mol Cell Biol 6 248-261
[4]  
Bouillaud F(2005)Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3 Cell Metab 2 85-93
[5]  
Krauss S(2001)Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers FASEB J 15 1071-1073
[6]  
Zhang CY(2000)Energy metabolism in uncoupling protein 3 gene knockout mice J Biol Chem 275 16258-16266
[7]  
Lowell BB(2000)Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3 J Biol Chem 275 16251-16257
[8]  
Brand MD(2006)Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak J Appl Physiol 101 339-347
[9]  
Esteves TC(2003)Pharmacology: uncoupling the agony from ecstasy Nature 426 403-404
[10]  
Hesselink MKC(2001)Biochemistry and molecular cell biology of diabetic complications Nature 414 813-820