Carcinogenic metals and NF‐κB activation

被引:0
作者
Fei Chen
Min Ding
Vince Castranova
Xianglin Shi
机构
[1] National Institute for Occupational Safety and Health,Health Effects Laboratory Division
来源
Molecular and Cellular Biochemistry | 2001年 / 222卷
关键词
NF‐κB; IKK; metals; signal transduction; ROS;
D O I
暂无
中图分类号
学科分类号
摘要
Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, and nickel. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-κB, a transcription factor governing the expression of most early response genes involved in a number of human diseases.
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页码:159 / 171
页数:12
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