Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways

被引：0
作者：
Xiaoling Chen
Yanliu Luo
Zhiqing Huang
Gang Jia
Guangmang Liu
Hua Zhao
机构：
[1] Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education,
[2] Institute of Animal Nutrition,undefined
[3] Sichuan Agricultural University,undefined
来源：
Scientific Reports | / 7卷
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摘要：
Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms.
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