In vivo generation and regeneration of β cells in zebrafish

被引：11
作者：
Yang B. [1 ]
Covington B.A. [1 ]
Chen W. [1 ]
机构：
[1] Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, 37232, TN
来源：
Cell Regeneration | / 9卷 / 1期
关键词：
D O I：
10.1186/s13619-020-00052-6
中图分类号：
学科分类号：
摘要：
The pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Although β-cell regeneration occurs in animal models under certain conditions, human β cells are refractory to proliferation. A better understanding of both the positive and the negative regulatory mechanisms of β-cell regeneration in animal models is essential to develop novel strategies capable of inducing functional β cells in patients. Zebrafish are an attractive model system for studying β-cell regeneration due to the ease to which genetic and chemical-genetic approaches can be used as well as their high regenerative capacity. Here, we highlight the current state of β-cell regeneration studies in zebrafish with an emphasis on cell signaling mechanisms. © 2020, The Author(s).
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