Expression of interleukin-17 and its clinical significance in gastric cancer patients

被引:0
作者
Xin Ying Meng
Chang Hong Zhou
Jian Ma
Chen Jiang
Ping Ji
机构
[1] Medical College of Qingdao University,Department of Health Care, Qingdao Municipal Hospital (East)
[2] Medical College of Qingdao University,Department of Pathology, Qingdao Municipal Hospital (West)
来源
Medical Oncology | 2012年 / 29卷
关键词
Interleukin 17; Gastric cancer; Microvessel density; Tissue;
D O I
暂无
中图分类号
学科分类号
摘要
To investigate the expression of interleukin 17 (IL-17) in serum and tumor tissues, and evaluate the correlation between IL-17 and clinical characteristics from patients with gastric cancer. From January 2009 to January 2010, total 50 patients with gastric cancer and 50 healthy controls were enrolled. The patients included 32 males and 18 females with average age of (62.05 ± 11.98) years. The concentration of serum IL-17 was detected by ELISA. Intratumoral IL-17 expression and microvessel density (MVD) were examined by immunohistochemical staining. Compared with healthy controls, patients with gastric cancer had higher levels of IL-17 in serum (p < 0.01) and cancer tissues. High expression of IL-17 was associated with high MVD (p < 0.01). IL-17 in cancer tissues was associated with the clinical stage of the tumors (p < 0.01) and lymph node metastasis (p < 0.05). No statistically significant correlation between the serum IL-17 and the clinical pathological features was found. Increased expression of IL-17 was seen in patient with gastric cancer. IL-17 may be involved in the progression of gastric cancer by promoting angiogenesis in tumor microenvironment.
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页码:3024 / 3028
页数:4
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