PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis

被引:0
作者
Songyang Liu
Chenxi Cao
Yujun Zhang
Guangyu Liu
Weixia Ren
Yanqi Ye
Tiezheng Sun
机构
[1] Peking University,Arthritis Clinic and Research Center, People’s Hospital
[2] Peking University,Institute of Sports Medicine, Peking University Third Hospital
[3] Peking University ,The Institute of Clinical molecular Biology and the Central Lab, Peking University, People’s Hospital
来源
Journal of Orthopaedic Surgery and Research | / 14卷
关键词
PI3K/Akt inhibitor; TNF-α; Cadherin-11; Osteoarthritis; Fibroblast-like synoviocytes;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Long Non-coding RNA THRIL Mediates Cell Growth and Inflammatory Response of Fibroblast-Like Synoviocytes by Activating PI3K/AKT Signals in Rheumatoid Arthritis
    Yongjian Liang
    He Li
    Xianbin Gong
    Chao Ding
    Inflammation, 2020, 43 : 1044 - 1053
  • [22] Long Non-coding RNA THRIL Mediates Cell Growth and Inflammatory Response of Fibroblast-Like Synoviocytes by Activating PI3K/AKT Signals in Rheumatoid Arthritis
    Liang, Yongjian
    Li, He
    Gong, Xianbin
    Ding, Chao
    INFLAMMATION, 2020, 43 (03) : 1044 - 1053
  • [23] Macrophage extracellular traps promote tumor-like biologic behaviors of fibroblast-like synoviocytes through cGAS-mediated PI3K/Akt signaling pathway in patients with rheumatoid arthritis
    Weng, Weizhen
    Liu, Yan
    Hu, Zuoyu
    Li, Zhihui
    Peng, Xiaohua
    Wang, Manli
    Dong, Bo
    Zhong, Shuyuan
    Jiang, Yutong
    Pan, Yunfeng
    JOURNAL OF LEUKOCYTE BIOLOGY, 2024, 115 (01) : 116 - 129
  • [24] D-Lactate Increases Cytokine Production in Bovine Fibroblast-Like Synoviocytes via MCT1 Uptake and the MAPK, PI3K/Akt, and NFκB Pathways
    Manosalva, Carolina
    Quiroga, John
    Teuber, Stefanie
    Cardenas, Sebastian
    Daniella Carretta, Maria
    Moran G, Gabriel
    Alarcon, Pablo
    Angelica Hidalgo, Maria
    Agustin Burgos, Rafael
    ANIMALS, 2020, 10 (11): : 1 - 17
  • [25] Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis
    Jiao, Zhijun
    Wang, Wenhong
    Ma, Jie
    Wang, Shengjun
    Su, Zhaoliang
    Xu, Huaxi
    CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012,
  • [26] PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis
    Li, Xiao-feng
    Yin, Shu-qin
    Li, Hao
    Yang, Ying-li
    Chen, Xin
    Song, Biao
    Wu, Sha
    Wu, Yuan-yuan
    Wang, Hua
    Li, Jun
    ACTA PHARMACOLOGICA SINICA, 2023, 44 (02) : 454 - 464
  • [27] PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis
    Xiao-feng Li
    Shu-qin Yin
    Hao Li
    Ying-li Yang
    Xin Chen
    Biao Song
    Sha Wu
    Yuan-yuan Wu
    Hua Wang
    Jun Li
    Acta Pharmacologica Sinica, 2023, 44 : 454 - 464
  • [28] PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
    Li, Guo-Qing
    Zhang, Yu
    Liu, Dan
    Qian, Ya-Yun
    Zhang, Hua
    Guo, Shi-Yu
    Sunagawa, Masataka
    Hisamitsu, Tadashi
    Liu, Yan-Qing
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 372 (1-2) : 221 - 231
  • [29] LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-α stimulation
    Zhang, Y.
    Wang, S.
    Dong, H.
    Yi, X.
    Zhang, J.
    Liu, X.
    Zhuang, R.
    Ding, Y.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2018, 192 (02) : 193 - 205
  • [30] TNF-α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis
    Li, Hongxi
    Xie, Shujuan
    Qi, Yunlong
    Li, Huazhe
    Zhang, Rui
    Lian, Yongyun
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) : 4737 - 4744