Ultrasensitive dynamic light scattering immunosensing platform for NT-proBNP detection using boronate affinity amplification

被引：0
作者：
Jiaqi Hu
Lu Ding
Jing Chen
Jinhua Fu
Kang Zhu
Qian Guo
Xiaolin Huang
Yonghua Xiong
机构：
[1] Nanchang University,State Key Laboratory of Food Science and Technology, School of Food Science and Technology
[2] The First Affiliated Hospital of Nanchang University,Hypertension Research Institute of Jiangxi Province, Department of Cardiology
[3] Jiangxi Agricultural Technology Extension Center,undefined
[4] Jiangxi-OAI Joint Research Institute,undefined
[5] Nanchang University,undefined
来源：
Journal of Nanobiotechnology | / 20卷
关键词：
Dynamic light scattering; Boronate affinity; Aggregation; Immunosensor; NT-proBNP;
D O I：
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中图分类号：
学科分类号：
摘要：
We developed a new DLS immunosensing technology for the rapid and sensitive detection of glycoprotein NT-proBNP.The boronate affinity recognition amplified nanoparticle aggregation was designed to enable highly sensitive DLS transduction.The fabricated DLS immunosensor exhibited ultrahigh sensitivity with an LOD of 7.4 fg mL−1, fast response time (< 20 min), and small sample consumption (1 μL).This boronate affinity amplified-DLS immunosensor has broad prospects for field or point-of-care testing of cis-diol-containing molecules.
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