Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia

被引：0
作者：
E Tagliafico
E Tenedini
R Manfredini
A Grande
F Ferrari
E Roncaglia
S Bicciato
R Zini
S Salati
E Bianchi
C Gemelli
M Montanari
T Vignudelli
T Zanocco-Marani
S Parenti
P Paolucci
G Martinelli
P P Piccaluga
M Baccarani
G Specchia
U Torelli
S Ferrari
机构：
[1] Sezione di Chimica Biologica,Dipartimento di Scienze Biomediche
[2] Università di Modena e Reggio Emilia,Dipartimento di Processi Chimici dell'Ingegneria
[3] Università di Padova,Dipartimento Materno Infantile
[4] Sezione di Oncoematologia Pediatrica,Dipartimento di Scienze Mediche e del Lavoro
[5] Università di Modena e Reggio Emilia,undefined
[6] Istituto di Ematologia ed Oncologia Medica ‘L. e A. Seragnoli’,undefined
[7] Università di Bologna,undefined
[8] Università di Foggia,undefined
[9] Ematologia,undefined
来源：
Leukemia | 2006年 / 20卷
关键词：
gene expression profiling; microarrays; acute myeloid leukemia; differentating therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acute myeloid leukemia (AML) blasts are immature committed myeloid cells unable to spontaneously undergo terminal maturation, and characterized by heterogeneous sensitivity to natural differentiation inducers. Here, we show a molecular signature predicting the resistance or sensitivity of six myeloid cell lines to differentiation induced in vitro with retinoic acid or vitamin D. The identified signature was further validated by TaqMan assay for the prediction of response to an in vitro differentiation assay performed on 28 freshly isolated AML blast populations. The TaqMan assay successfully predicts the in vitro resistance or responsiveness of AML blasts to differentiation inducers. Furthermore, performing a meta-analysis of publicly available microarray data sets, we also show the accuracy of our prediction on known phenotypes and suggest that our signature could become useful for the identification of patients eligible for new therapeutic strategies.
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页码：1751 / 1758
页数：7
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共 225 条
  • [1] Tallman MS(2004)Acute promyelocytic leukemia as a paradigm for targeted therapy Semin Hematol 41 27-32
  • [2] Manfredini R(1999)Induction of a functional vitamin D receptor in all- Cancer Res 59 3803-3811
  • [3] Trevisan F(2005)-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells Cancer Res 65 2488-2497
  • [4] Grande A(2000)19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia Leukemia 14 491-496
  • [5] Tagliafico E(2000)Differentiation therapy in acute myelogenous leukemia (non-APL) Stem Cells 18 157-165
  • [6] Montanari M(1999)New strategies for the treatment of acute myelogenous leukemia: differentiation induction – present use and future possibilities Science 286 531-537
  • [7] Lemoli R(2002)Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Proc Natl Acad Sci USA 99 10008-10013
  • [8] Kumagai T(2003)Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles Genes Chromosomes Cancer 37 396-405
  • [9] Shih LY(2003)Molecular characterization of acute leukemias by use of microarray technology Genes Chromosomes Cancer 37 149-158
  • [10] Hughes SV(2004)Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events N Engl J Med 350 1617-1628
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