Microsystem for Stem Cell-Based Cardiovascular Research

被引：3

作者：

Yang, Huaxiao ^{[1
]}

Ma, Zhen ^{[2
]}

机构：

[1] Department of Bioengineering, Clemson University, Clemson

[2] Department of Bioengineering, University of California, Berkeley, CA 94720

来源：

BioNanoScience | 2012年 / 2卷 / 04期

关键词：

Cardiac tissue engineering; Cell patterning; Heart on a chip; Microsystem; Regenerative medicine; Stem cell biology;

D O I：

10.1007/s12668-012-0064-3

中图分类号：

学科分类号：

摘要：

The emergence of microsystem offers a tool to analyze the biophysical and biochemical functions of individual cells for biosensing, disease diagnostics, drug screening, and fundamental research. With the rapid expansion and eager need for stem cell-based regenerative medicine, introducing microsystem to stem cell research allows locating, culturing, and reprogramming stem cells under a highly controlled microenvironment, including geometrical restriction, surface biochemistry, extracellular matrix (ECM) composites, and cell-cell interactions. This review focused on the application of microtechnology in stem cell-based cardiovascular research to discuss the creation of biomimetic cardiac microenvironment and its influence on stem cell cardiomyogenic differentiation and stem cell-cardiomyocyte interaction. This review was divided into four sections: three-dimensional tissue construction, two-dimensional cell alignment, single-cell micropatterning and analysis, and development of advanced microsystem heart-on-a-chip". © 2012 Springer Science+Business Media New York."

引用

页码：305 / 315

页数：10

共 67 条

[1]

Ghafar-Zadeh E., Waldeisen J.R., Lee L.P., Engineered approaches to the stem cell microenvironment for cardiac tissue regeneration, Lab on a Chip, 11, pp. 3031-3048, (2011)

[2]

Oettgen P., Boyle A.J., Schulman S.P., Hare J.M., Cardiac stem cell therapy. Need for optimization of efficacy and safety monitoring, Circulation, 114, pp. 353-358, (2006)

[3]

Mummery C., Ward-van oostwaard D., Doevendans P., Spijker R., van den Brink S., Hassink R., Et al., Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells, Circulation, 107, pp. 2733-2740, (2003)

[4]

Penn M.S., von Recum H.A., A tale of 2 biologies: stem cell patch: myocardial interactions are critical for myocardial regeneration, Journal of the American College of Cardiology, 58, pp. 2128-2129, (2011)

[5]

Bel A., Planat-Bernard V., Saito A., Bonnevie L., Bellamy V., Sabbah L., Et al., Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells, Circulation, 122, (2010)

[6]

Valarmathi M.T., Goodwin R.L., Fuseler J.W., Davis J.M., Yost M.J., Potts J.D., A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration, Biomaterials, 31, pp. 3185-3200, (2010)

[7]

Takahashi K., Yamanaka S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 126, pp. 663-676, (2006)

[8]

Laflamme M.A., Gold J., Xu C., Hassanipour M., Rosler E., Police S., Et al., Formation of human myocardium in the rat heart from human embryonic stem cells, American Journal of Pathology, 167, pp. 663-671, (2005)

[9]

Ben-David U., Benvenisty N., The tumorigenicity of human embryonic and induced pluripotent stem cells, Nature Reviews. Cancer, 11, pp. 268-277, (2011)

[10]

Pfister O., Mouquet F., Jain M., Summer R., Helmes M., Fine A., Et al., CD31- but not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation, Circulation Research, 97, pp. 52-61, (2005)

← 1 2 3 4 5 6 7 →