Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles containing a sterically hindered 4-hydroxy-3,5-di(tert-butyl)phenyl group

被引：0
作者：
Kelarev V.I. [1 ]
Koshelev V.N. [1 ]
Silin M.A. [1 ]
机构：
[1] I. M. Gubkin State Oil and Gas Academy
来源：
Chemistry of Heterocyclic Compounds | 1997年 / 33卷 / 6期
关键词：
Organic Chemistry; Phenyl; Hydrochloride; Hydrazine; Benzoyl;
D O I：
10.1007/BF02291806
中图分类号：
学科分类号：
摘要：
A series of 2,5-disubstituted 1,3,4-oxadiazoles containing one or two 4-hydroxydi(tert-butyl)phenyl groups has been synthesized. These sterically hindered compounds were prepared by condensation of acids containing the indicated fragment and their derivatives with hydrazine dihydrochloride, hydrazides, and hydrochlorides of iminoesters of acids, by the reaction of 4-hydroxy-3,5-di(tert-butyl)thiphenol with 2-chloromethylsubstituted 1,3,4-oxadiazoles in the presence of KOH, and by cyclodehydration of N-acyl-N′-[4-hydroxy-3,5-di(tert-butyl)benzoyl]hydrazones under action of POCl3. ©1997 Plenum Publishing Corporation.
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页码：718 / 723
页数：5
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