Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 2: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs and Drugs Used to Treat Non-Epilepsy Disorders

被引：0
作者：
Philip N. Patsalos
机构：
[1] UCL,Department of Clinical and Experimental Epilepsy, Institute of Neurology
[2] Epilepsy Society,undefined
[3] Chalfont Centre for Epilepsy,undefined
来源：
Clinical Pharmacokinetics | 2013年 / 52卷
关键词：
Lamotrigine; Topiramate; Pregabalin; Vigabatrin; Oxcarbazepine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since antiepileptic drugs (AEDs) are prescribed to treat various non-epilepsy-related disorders in addition to the fact that patients with epilepsy may develop concurrent disorders that will need treatment, the propensity for AEDs to interact with non-AEDs is considerable and indeed can present a difficult clinical problem. The present review details the pharmacokinetic and pharmacodynamic interactions that have been reported to occur with the new AEDs (eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, pregabalin, retigabine (ezogabine), rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide) and drugs used to treat non-epilepsy disorders. Interaction study details are described, as necessary, so as to allow the reader to take a view as to the possible clinical significance of particular interactions. Pharmacokinetic interactions relate to hepatic enzyme induction or inhibition and involved a variety of drugs including psychoactive drugs, cardioactive drugs, oral contraceptives, antituberculous agents, analgesics and antineoplastic drugs. A total of 68 pharmacokinetic interactions have been described, with lamotrigine (n = 22), topiramate (n = 18) and oxcarbazepine (n = 7) being associated with most, whilst lacosamide, pregabalin, stiripentol and vigabatrin are associated with none. Overall, only three pharmacodynamic interactions have been described and occur with oxcarbazepine, perampanel and pregabalin.
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页码：1045 / 1061
页数：16
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  • [41] Lal R(2000)Pharmacokinetic profile of levetiracetam: toward ideal characteristics Pharmacol Ther 85 77-1734
  • [42] Sukbuntherng J(1991)Oxcarbazepine-verapamil drug interaction in healthy volunteers [abstract] Epilepsia 32 70-203
  • [43] Luo W(1994)Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy Acta Neurol Scand 90 130-787
  • [44] Vicente V(2001)Possible oxcarbazepine interaction with cyclosporine serum levels: a single case study Clin Neuropharmacol 24 113-484
  • [45] Blumenthal R(1993)Influence of single and repeated doses of oxcarbazepine on the pharmacokinetic profile of felodipine Ther Drug Monit 15 39-18
  • [46] Ho J(2003)European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme Ann Oncol 14 1732-93
  • [47] Sternieri E(2008)Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients Curr Clin Pharmacol 3 198-890
  • [48] Coccia CP(1999)Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women Epilepsia 40 783-1141
  • [49] Pinetti D(2008)Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride Gen Hosp Psychiatry 30 482-382
  • [50] Guerzoni S(2004)Pregabalin pharmacology and its relevance to clinical practice Epilepsia 45 13-780
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