Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 2: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs and Drugs Used to Treat Non-Epilepsy Disorders

被引：0
作者：
Philip N. Patsalos
机构：
[1] UCL,Department of Clinical and Experimental Epilepsy, Institute of Neurology
[2] Epilepsy Society,undefined
[3] Chalfont Centre for Epilepsy,undefined
来源：
Clinical Pharmacokinetics | 2013年 / 52卷
关键词：
Lamotrigine; Topiramate; Pregabalin; Vigabatrin; Oxcarbazepine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since antiepileptic drugs (AEDs) are prescribed to treat various non-epilepsy-related disorders in addition to the fact that patients with epilepsy may develop concurrent disorders that will need treatment, the propensity for AEDs to interact with non-AEDs is considerable and indeed can present a difficult clinical problem. The present review details the pharmacokinetic and pharmacodynamic interactions that have been reported to occur with the new AEDs (eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, pregabalin, retigabine (ezogabine), rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide) and drugs used to treat non-epilepsy disorders. Interaction study details are described, as necessary, so as to allow the reader to take a view as to the possible clinical significance of particular interactions. Pharmacokinetic interactions relate to hepatic enzyme induction or inhibition and involved a variety of drugs including psychoactive drugs, cardioactive drugs, oral contraceptives, antituberculous agents, analgesics and antineoplastic drugs. A total of 68 pharmacokinetic interactions have been described, with lamotrigine (n = 22), topiramate (n = 18) and oxcarbazepine (n = 7) being associated with most, whilst lacosamide, pregabalin, stiripentol and vigabatrin are associated with none. Overall, only three pharmacodynamic interactions have been described and occur with oxcarbazepine, perampanel and pregabalin.
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页码：1045 / 1061
页数：16
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  • [1] Johannessen LC(2008)Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy CNS Drugs 22 27-47
  • [2] Patsalos PN(2002)The importance of drug interactions in epilepsy therapy Epilepsia 43 365-385
  • [3] Froscher W(2009)Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects Fundam Clin Pharmacol 23 509-514
  • [4] Pisani F(2009)Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects Int J Clin Pharmacol Ther 47 255-261
  • [5] van Rijn CM(2012)Pharmacokinetics and drug interactions of eslicarbazepine acetate Epilepsia 53 935-946
  • [6] da Vaz SM(2010)Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study Clin Ther 32 179-192
  • [7] Costa R(1995)Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive Clin Pharmacol Ther 58 523-531
  • [8] Soares E(1994)Warfarin-felbamate interaction: first report Ann Pharmacother 28 805-507
  • [9] Maia J(1992)Effect of Maalox TC on single-dose pharmacokinetics of gabapentin capsules in healthy subjects [abstract] Pharm Res 9 S315-1007
  • [10] Falcao A(2010)Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine Br J Clin Pharmacol 69 498-355
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